The Baltic Medical Centre’s Non-Invasive Prenatal Test or NIPT in Canary Wharf, London is an advanced and revolutionary method for detecting genetic abnormalities in the fetus during pregnancy. Using advanced sequencing technology it analysis cell-free DNA circulating in the pregnant mother’s blood.
Chromosomal abnormalities can occur in any pregnancy. NIPT test screens for the most common ones:
- Trisomy 21 (Down’s Syndrome), Trisomy 18 (Edward’s Syndrome), and Trisomy 13 (Patau’s Syndrome)
- Sex Chromosome anomalies X(O) – Turner’s Syndrome, XXY – Klinefelter’s Syndrome, XYY – Jacob’s Syndrome, XXX – Tripe X Syndrome
- It can also be used to tell the sex of the baby (optional).
A blood test is taken from the mother as early as 10 weeks of pregnancy (but not earlier) to evaluate possible chromosomal conditions in the baby. NIPT is more accurate than traditional first-trimester screening tests, it gives fewer false positive alarms and is proven by clinical evidence. NIPT is now endorsed by American College of Obstetricians and Gynaecologists and Society for Maternal-Fetal Medicine for all pregnant mothers regardless of age or risk.
How is the test done?
An ultrasound scan is always done first to ensure the baby is healthy and developing normally. If the baby does not measure over 10 weeks gestation at the scan, it is too early for the test. Our experienced doctors will give counselling on the pros and cons of prenatal screening and help you choose the best test for your circumstances. The mother will then have a blood sample taken from her arm (just like any other blood test) and it will be sent to the advanced UK based laboratory for analysis. Being non-invasive, it is completely safe for the mother and baby. The results take 3-10 days to come back. Kindly note that some clinics are providing NIPT appointments conducted by sonographers or nurses who lack clinical authorisation, thereby being unable to offer clinical guidance regarding prenatal testing or the interpretation of test outcomes!
What do the results mean?
NIPT has >99% detection rate for aneuploidies. The NIPT is a screening test so you will not get a positive or negative result. The results are ‘high probability’ and ‘low probability’.
A high probability result usually means you will be referred for detailed ultrasound scans, invasive testing, counselling, and referral to another specialist to confirm whether or not your baby has the condition.
How much NIPT test cost in London?
|T21, T18 and T13, gender detection and sex chromosome anomalies.
|Test Price: £300
A consultation with an experienced gynaecologist and an ultrasound scan costs £230 (mandatory).
10 or more weeks of pregnancy? Schedule your NIPT appointment today! Choose a convenient date and time, and book your consultation and ultrasound scan. During the appointment, eligible patients will discuss and select the most suitable NIPT from the available options (additional cost).
Non-Invasive Prenatal Test FAQs
What’s the reason for undergoing the test?
NIPT identifies anomalies as early as week 10 with high precision and minimal false positives.
How does the test work?
The test entails a straightforward blood extraction from the expectant mother’s arm, containing both maternal and fetal DNA. Non-Invasive Pre-Natal tests aid in determining potential chromosomal conditions in your baby.
What’s the level of accuracy?
This Illumina NIPT boasts a detection rate of over 99% for aneuploidies.
What is a trisomy?
Typically, the human body comprises 46 chromosomes in every cell, organised as 23 pairs. These pairs encompass all the DNA necessary to assess the baby’s well-being. In some cases, genetic irregularities arise when a baby acquires three copies of a specific chromosome instead of the usual two. The risk of having a chromosomal condition increases as the mother gets older.
What is Trisomy 21?
Trisomy 21 is a condition that is caused by an extra chromosome number 21 (three copies
instead of two). Individuals with trisomy 21 have variable physical features and intellectual disability. Some common features of trisomy 21 include heart defects, duodenal atresia, low muscle tone, and differences in facial features. Some of these structural findings may be identified in second
trimester ultrasound evaluation. Trisomy 21 is the most common chromosome anomaly, occurring in 1 in 700 to 800 live births.
What is trisomy 18?
Trisomy 18 is a condition that is caused by an extra chromosome number 18 (three copies instead of two). Individuals with trisomy 18 have severe intellectual disability and abnormalities involving multiple organs. Some of the common features of trisomy 18 include heart defects, brain abnormalities, musculoskeletal problems, cleft lip and palate, clenched hand, and low birth weight. Trisomy 18 occurs in 1 in 6000 to 8000 live births.
What is trisomy 13?
Trisomy 13 is a condition that is caused by an extra chromosome number 13 (three copies instead of two). Individuals with trisomy 13 have severe intellectual disability and abnormalities involving multiple organs. Some of the common features of trisomy 13 include heart defects, omphalocele, brain abnormalities such as holoprosencephaly, cleft lip and palate, and other features. Trisomy 13 occurs in approximately 1 in 12,000 live births.
What are sex chromosome aneuploidies?
Sex chromosome anomalies (SCA) occur when there is a missing, extra or partial/incomplete sex chromosome (X or Y).
The NIPT looks for SCAs such as:
X(O) – Turners Syndrome A condition affecting females, due to partially or completely missing sex chromosome. Most of them can lead a normal life with regular medical care.
XXY – Klinefelter’s syndrome is an aneuploid genetic condition where a male has an additional copy of the X chromosome. The primary features are infertility and small, poorly functioning testicles
XYY- Jacob’s syndrome is a genetic condition having an extra copy of the Y chromosome in each of a male’s cells, the chromosomal change sometimes causes no unusual physical features
XXX- Triple X syndrome A genetic disorder characterized by the presence of an additional X chromosome in female children. They are often taller than average girls.
How accurate are NIPT results?
NIPT are extremely accurate. The test identifies 99.9% of pregnancies with trisomy 13, trisomy 18, or trisomy 21.
Can I pre-book NIPT test at your Canary Wharf medical centre in advance?
Yes, you can book the appointment for a future date that falls after the completion of 10 weeks of gestation (pregnancy).
How long does it take to get results?
Our clinician will share results and comments by email within 3-7 working days, once samples reach the laboratory in the UK.
Is this NIPT valid for twin pregnancies?
Yes, we can report NIPT on twin pregnancies, but the result will only be able to say the likelihood of an affected pregnancy, it cannot tell which Twin or if both Twins are affected.
What if I have Vanishing twin syndrome pregnancy?
NIPT is not advised if you have a vanishing or demised twin pregnancy.
How do you report fetus sex in twin pregnancy?
The laboratory will only be able to determine that you have a pregnancy with 2 girls, or a pregnancy with at least 1 male.
Limitations of NIPT
The VeriSeq NIPT Solution v2 is not validated for use in pregnancies with more than two fetuses, fetal demise, mosaicism, partial chromosome aneuploidy, triploidy, translocations, maternal aneuploidy, transplant or malignancy. VeriSeq NIPT Solution v2 does not detect neural tube defects. Certain rare biological conditions may also affect the accuracy of the test.
For twin pregnancies, HIGH PROBABILITY test results apply to at least one fetus; male test results apply to one or both fetuses; female test results apply to both fetuses. Due to the limitations of the test, inaccurate results are possible.
A LOW PROBABILITY result does not guarantee that a fetus is unaffected by a chromosomal or genetic condition. Some non-aneuploid fetuses may have HIGH PROBABILITY results. In cases of HIGH PROBABILITY results and/or other clinical indications of a chromosomal condition, confirmatory testing is necessary for diagnosis.